6 Degrees of Separation: -80°C (Part 4)

Testo-Pharma-Blog-4-Image-1.jpg

Welcome back temperature sleuths!  Today we are discussing another important storage temperature within the life sciences industry.  The Ultracold or -80°C temperature is another crucial temperature for long term storage of materials that require stable, controlled, deeply frozen environments.  The ultracold temperature is essential in storage of biological materials to stunt or stop degradation of samples at the cellular level over time.  The -80°C temperature stops the degradation of nucleic acids, proteins, endocrine molecules, and many other biological molecules.

If you are considering the purchase of an ultracold freezer, as a first step you should develop a clear list of user requirements.  This includes operating range and control accuracy of the unit.  You can also differentiate between ultracold freezer compressor technology.  You should investigate ultracold freezers that do not use old compressor technology as wear and tear of compressors affects the cooling of the unit over a shorter and longer period.  Older oil compressor technology creates large valleys and peaks within defrost cycles which in turn affects sample stability and degradation.  Ultracold freezers that use free-piston engines which use a reciprocating piston and displacer, along with a continuous gravity driven thermosiphon cool the ultracold freezer cabinet interior while allowing for less valleys and peaks within defrost cycles and a more stable freezer environment to protect biological samples.

 Just like laboratory grade fridges, ultracold freezers need to be initially thermally validated, continuously monitored, and periodically performance checked depending on FDA regulatory requirements. For more information view our Mapping Services White Paper

Now that you have validated or qualified the ultracold freezer, you need to install a monitoring system that can continuously monitor temperature while alerting users to any temperature deviations outside of the temperature alarm setpoint.  The system should have a FDA compliant 21 CFR Part 11 certified software that is easy to use while also being secure.

Tune in next week for our discussion about 32°C temperatures, or as I like to say, “Is it getting a unpleasantly warm in here!?!?”.
 

Testo-Pharma-Blog-4-Image-2.jpg
Help

0507e66081f3cb4e14f89178811da7eb9f09c303
Confirm
Found draft
Found draft
Found drafts
Existing form data found
Form Submitted
Review Form Validation Messages
Unable to complete action
Confirmation

Stay Informed!

Subscribe to receive the latest industry information focusing on Testo Pharma Solutions.

digitales-handwerk-zusammenarbeit-neu-gedacht.jpeg